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Viewing: Blog Posts Tagged with: DNA, Most Recent at Top [Help]
Results 1 - 25 of 47
1. The early promise of “liquid” cancer tests

A powerful technology that continues to evolve, researchers say, has rekindled interest in liquid biopsies as a way to disrupt tumor progression. The technology, genetic sequencing, is allowing researchers a closer look at the genetic trail tumors leave in the blood as cancer develops. That capability, as these new “liquid” blood tests work their way into clinics, may further a deeper understanding of how tumors alter their molecular masks to defy treatment.

The post The early promise of “liquid” cancer tests appeared first on OUPblog.

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2. Genome editing’s brave new world

“O, wonder!/How many goodly creatures are there here!/How beauteous mankind is!/O brave new world,/That has such people in't!” Shakespeare’s lines in The Tempest famously inspired Aldous Huxley’s novel Brave New World, first published in 1932. Huxley’s vision of the future has become a byword for the idea that attempts at genetic (and social) engineering are bound to go wrong. With its crude partitioning of society, by stunting human development before birth, and with its use of a drug – soma – to induce a false sense of happiness and suppress dissent, this was the opposite of a ‘beauteous’ world.

The post Genome editing’s brave new world appeared first on OUPblog.

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3. Defining biodiversity genomics

Many say now is the century of biology, the study of life. Genomics is therefore “front-and-centre”, as DNA, is the software of life. From staring at stars, we are now staring at DNA. We can’t use our eyes, like we do in star gazing, but just as telescopes show us the far reaches of the Universe, DNA sequencing machines are reading out our genomes at an astonishing pace.

The post Defining biodiversity genomics appeared first on OUPblog.

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4. The Cancer Moonshot

Announced on January 13th by President Obama in his eighth and final State of the Union Address, the multi-billion dollar project will be led by US Vice President, Joe Biden, who has a vested interest in seeing new cures for cancer. Using genomics to cure cancer is being held on par with JFK’s desire in 1961 to land men on the moon.

The post The Cancer Moonshot appeared first on OUPblog.

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5. We should all eat more DNA

2016 is here. The New Year is a time for renewal and resolution. It is also a time for dieting. Peak enrolment and attendance times at gyms occur after sumptuous holiday indulgences in December and again when beach wear is cracked out of cold storage in summer. As the obesity epidemic reaches across the globe we need new solutions. We need better ways to live healthy lifestyles.

The post We should all eat more DNA appeared first on OUPblog.

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6. Will we ever know for certain what killed Simón Bolívar?

When Simón Bolívar died on this day 185 years ago, tuberculosis was thought to have been the disease that killed him. An autopsy showing tubercles of different sizes in his lungs seemed to confirm the diagnosis, though neither microscopic examination nor bacterial cultures of his tissues were performed.

The post Will we ever know for certain what killed Simón Bolívar? appeared first on OUPblog.

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7. The magic of Christmas: it’s Santa’s DNA

Knowledge that we all have DNA and what this means is getting around. The informed public is well aware that our cells run on DNA software called the genome. This software is passed from parent to child, in the long line of evolutionary history that dates back billions of years – in fact, research published this year pushes back the origin of life on Earth another 300 million years.

The post The magic of Christmas: it’s Santa’s DNA appeared first on OUPblog.

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8. Wine and DNA profiling

In ampelographic collections, about ten living plants of each grape variety or clone are kept alive for future studies or plantings, which requires a large amount of time and money. Yet, in every collection we estimate an average of 5% of labelling errors. They can now be identified with DNA profiling and duplicates can be eliminated, thus saving time and money.

The post Wine and DNA profiling appeared first on OUPblog.

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9. The Angelina Jolie effect

It is hard to quantify the impact of ‘role-model’ celebrities on the acceptance and uptake of genetic testing and bio-literacy, but it is surely significant. Angelina Jolie is an Oscar-winning actress, Brad Pitt’s other half, mother, humanitarian, and now a “DNA celebrity”. She propelled the topic of familial breast cancer, female prophylactic surgery, and DNA testing to the fore.

The post The Angelina Jolie effect appeared first on OUPblog.

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10. Why know any algebra?

A recent meme circulating on the internet mocked a US government programme (ObamaCare) saying that its introduction cost $360 million when there were only 317 million people in the entire country. It then posed the rhetorical question: "Why not just give everyone a million dollars instead?"

The post Why know any algebra? appeared first on OUPblog.

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11. The rise of epigenetics and the demise of nature vs nurture

Epigenetics has been a buzzword in biology for the past several years, as scientific understanding has grown about how genes are expressed.

The post The rise of epigenetics and the demise of nature vs nurture appeared first on OUPblog.

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12. Evolution: Some difficult problems

Two other major and largely unsolved problems in evolution, at the opposite extremes of the history of life, are the origin of the basic features of living cells and the origin of human consciousness. In contrast to the questions we have just been discussing, these are unique events in the history of life.

The post Evolution: Some difficult problems appeared first on OUPblog.

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13. The woman who changed the world

Society owes a debt to Henrietta Lacks. Modern life benefits from long-term access to a small sample of her cells that contained incredibly unusual DNA. As Rebecca Skloot reports in her best-selling book, “The Immortal Life of Henrietta Lacks”, the story that unfolded after Lacks died at the age of 31 is one of injustice, tragedy, bravery, innovation and scientific discovery.

The post The woman who changed the world appeared first on OUPblog.

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14. Kuwait’s war on ISIS and DNA

Kuwait is changing the playing field. In early July, just days after the June 26th deadly Imam Sadiq mosque bombing claimed by ISIS, Kuwait ruled to instate mandatory DNA-testing for all permanent residents. This is the first use of DNA testing at the national-level for security reasons, specifically as a counter-terrorism measure. An initial $400 million dollars is set aside for collecting the DNA profiles of all 1.3 million citizens and 2.9 million foreign residents

The post Kuwait’s war on ISIS and DNA appeared first on OUPblog.

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15. International Kissing Day and DNA

Another ‘Awareness Day’, International Kissing Day, is coming up on July 6. It might not seem obvious but kissing, like most subjects can now be easily linked to the science of DNA. Thus, there could be no more perfect opener for my Double Helix column, given the elegance and beauty of a kiss. To start, there is the obvious biological link between kissing and DNA: propagation of the species. Kissing is not only pleasurable but seems to be a solid way to assess the quality and suitability of a mate.

The post International Kissing Day and DNA appeared first on OUPblog.

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16. TED Talks and DNA

One of the most fun and exciting sources of information available for free on the Internet are the videos found on the Technology, Entertainment and Design (TED) website. TED is a hub of stories about innovation, achievement and change, each artfully packaged into a short, highly accessible talk by an outstanding speaker. As of April 2015, the TED website boasts 1900+ videos from some of the most imminent individuals in the world. Selected speakers range from Bill Clinton and Al Gore to Bono and other global celebrities to a range of academics experts.

The post TED Talks and DNA appeared first on OUPblog.

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17. DNA: The amazing molecule

DNA is the foundation of life. It codes the instructions for the creation of all life on Earth. Scientists are now reading the autobiographies of organisms across the Tree of Life and writing new words, paragraphs, chapters, and even books as synthetic genomics gains steam. Quite astonishingly, the beautiful design and special properties of DNA makes it capable of many other amazing feats. Here are five man-made functions of DNA, all of which are contributing to the growing “industrial-DNA” phenomenon.

The post DNA: The amazing molecule appeared first on OUPblog.

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18. DNA Day 2015: celebrating advances in genetics and gene therapy [infographic]

Today, 25 April is a joint celebration for geneticists, commemorating the discovery of the helix nature of DNA by James Watson and Francis Crick in 1953 and the completion of the human genome project fifty years later in 2003. It may have taken half a century to map the human genome, but in the years since its completion the field of genetics has seen breakthroughs increase at an ever-accelerating rate.

The post DNA Day 2015: celebrating advances in genetics and gene therapy [infographic] appeared first on OUPblog.

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19. Police Procedure & Investigation - A Must-Read Handbook for Mystery Writers


This book is part of the
Writer's Digest Howdunit
Series.
I mentioned in an earlier post that I’ve joined Sisters in Crime and the local chapter, Capitol Crimes. The local chapter meets monthly, and each month guest speakers share their expertise in either writing mysteries or being connected in some way to concerns of the mystery writer. One such concern is always whether a writer is presenting crime scenes or police procedures that are accurate. Last month we were fortunate to have Lee Lofland, the author of Police Procedure & Investigation, as our guest speaker, and he addressed those very concerns. 

Lee Lofland is a former police detective, and the bad news is that much of what you see on your favorite crime show is misleading and/or inaccurate. His book, on the other hand, is a very thorough coverage of everything an author would want to ask their local police department. Blurbs by best-selling mystery writers (including two of my favorites, Rhys Bowen and Hallie Ephron) give his book high praise, and I was pleased to find that the writing – entertaining and sobering by turns – is always a good read. He presents facts that you really want to know in a way that don’t make your eyes glaze over. A few examples:
The difference between police officers and detectives; how they’re trained; what they do.  
Arrest and search procedures.
The differences between homicide, murder, and manslaughter.
The difference between a crime scene and the scene of the crime.
DNA and fingerprinting
What can send you to prison and what can send you to jail.
A section on different drugs and the effects of each one.
Differences in weapons (with photos) and how they work

The book’s appendices include a glossary of terms, police 10 codes, a drug quantity table, and a federal sentencing table. It isn’t necessary to read this book straight through, chapter by chapter. There’s a thorough index that helps when you just want to look up something useful at that moment in your writing, along with good visual aids (charts, diagrams, photos of tools, etc.) throughout the book. This is a must read for any mystery writer who wants their police procedural scenes to ring with accuracy.

Lee also shared with us the Writers’ Police Academy, held in August in Appleton, Wisconsin. Yes, there really is such a thing. You can register now and have hands on experiences that will enhance your scenes. For more information about what is covered, check out their website HERE  .

Lee’s book is available in paperback and Kindle at Amazon HERE .

You can contact the Lee Lowland at his website, The Graveyard Shift, HERE, and learn even more about police work to enrich your mysteries from his frequent blog posts.  
The author and friendly officer.

A must have book.

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20. The King’s genes

On 25th March 2015, 530 years after his death, King Richard III of England will be interred in Leicester Cathedral. This remarkable ceremony is only taking place because of the success of DNA analysis in identifying his skeletal remains. So what sort of genes might a king be expected to have? Or, more prosaically, how do you identify a long dead corpse from its DNA? Several methods were used, and in particular the deduction of the skeleton’s probable hair and eye colour raises some interesting questions about future trends in forensic DNA analysis.

Richard III is one of England’s best known kings, largely due to the famous play of William Shakespeare in which he is portrayed as an evil villain. He only reigned for two years and was killed at the age of 32 at the battle of Bosworth in 1485. According to the historical records he was unceremoniously buried at Greyfriars Friary in Leicester. At some stage knowledge of the exact location of Richard’s burial was lost. But in 2012 excavations under a car park at the probable site of the former friary yielded “skeleton 1″. Suspicion of his royal identity was excited by the fact that the skeleton had a severely bent spine causing the right shoulder to be higher than the left. This well-known deformity of Richard was mentioned in a contemporary source, as well as by Shakespeare. Furthermore, the skeleton was male, the age was about right, it had evidently been killed in battle, and the radiocarbon date was consistent with death in 1485.

This was all very suggestive, but it was the DNA analysis that really proved the case. The work was led by a team at the University of Leicester, with participation by many other UK and European centres. It is important to note that this was not the normal type of forensic DNA identification, which relies on comparing a set of highly variable DNA markers to a database. Such analysis is fine so long as your suspect is in the database, but it is no use for identifying a long dead individual who is not in any database.

By far the best evidence for the identity of Richard III comes from the analysis of his mitochondrial DNA. Mitochondria are bodies found in every cell, responsible for the production of energy. They have their own DNA which is passed down the generations only through the female line. Barring the occasional new mutation, the DNA sequence of mitochondrial DNA should be identical from mother to daughter down a particular female line of descent. Like their sisters, males also carry the mitochondrial DNA of their mothers, but they do not pass it down to their own offspring.

Richard will have shared mitochondrial DNA with his sister, Anne of York. Two complete female lines of descent were traced back to Anne of York, one of 17 generations down to Michael Ibsen, a resident of London, and the other of 19 generations down to Wendy Duldig, formerly of New Zealand. Complete sequencing of their mitochondrial DNA showed a 100% match between skeleton 1 and of Michael Ibsen, and a single base change compared to Wendy Duldig. One change over this period of time is quite likely to be a new mutation. The sequence family (haplogroup) to which the mitochondrial DNA sequence belongs is a fairly rare one, so few other people in England in 1485 would have shared it and in fact the team has systematically ruled out all the other males of the period who might have shared it because of a common female lineage with Richard III. So this match is highly significant and is the best piece of evidence that the “skeleton 1″ is indeed King Richard.

By Bdna. gif: Spiffistan derivative work: Jahobr (Bdna.gif). Public domain via Wikimedia Commons

Also applied was a newer method which is a technique for predicting the hair and eye colour of someone from their DNA. The most important variants affecting hair colour are mutations of a gene called MC1R, which encodes a cell surface receptor for a hormone. Individuals carrying variants of the MC1R gene with reduced function are likely to have red or blond hair rather than the normal dark hair. The pigmentation of the iris of the eye depends significantly on a gene called OCA2, encoding a protein which transports tyrosine into cells. Again variants of reduced function give less pigmented eyes, meaning that the colour is blueish rather than brownish. Recently a Dutch group created a forensic test based on variants at 24 genetic loci, of which 11 are in the MC2R gene and the rest in 12 other positions including the OCA2 gene. Identification of these 24 variants yields a fairly accurate prediction of hair and eye colour, and in the case of skeleton 1 the prediction was for blue eyes and blond hair. The existing portraits of Richard III all date from some time after his death but the older ones do indeed show light-coloured eyes and reddish-brown hair, an appearance which is consistent with the prediction.

These two types of analysis indicate two rather different senses in which we use the word “gene”. The sequence variants of the mitochondrial DNA, like those used in normal forensic identification, do not, in general, affect the characteristics of the individuals carrying them. The DNA changes often lie outside actual genes, in the regions of DNA between genes. They are better described as “markers” than as “genes”. But the hair and eye colour analysis is based at least partly on actual gene variants that might be expected to generate those visible characteristics.

How much further might this kind of analysis be pushed? Could the height, facial features or skin colour of a crime suspect be deduced from their DNA? The essential issue is the number of gene variants in the population that affect a feature. If it is relatively small, as with hair and eye colour, then prediction is possible. If it is very large, as for height, then it is not possible, because most of the variants affecting height have too small effects to be detectable. Most of the human characteristics that have been studied in this way have turned out to depend on a very large number of variants of small effect. So, contrary to popular perception, there are real limits to what is possible in terms of prediction of bodily features from DNA data. There will doubtless be some other features that are predictable, and these may eventually include skin colour. But unless a completely new approach is invented, it is unlikely that we shall ever see an identikit picture of a suspect generated from DNA at the crime scene.

Featured image credit: Stained glass, by VeteranMP. CC-BY-SA 3.0 via Wikimedia Commons

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21. Discovering microbiology

Microbiology should be part of everyone’s educational experience. European students deserve to know something about the influence of microscopic forms of life on their existence, as it is at least as important as the study of the Roman Empire or the Second World War. Knowledge of viruses should be as prominent in American high school curricula as the origin of the Declaration of Independence. This limited geographic compass reflects the fact that the science of microbiology is a triumph of Western civilization, but the educational significance of the field is a global concern. We cannot understand life without an elementary comprehension of microorganisms.

Appreciation of the microbial world might begin by looking at pond water and pinches of wet soil with a microscope. Precocious children could be encouraged in this fashion at a very early age. Deeper inquiry with science teachers would build a foundation of knowledge for teenagers, before the end of their formal education or the pursuit of a university degree in the humanities.

Earth has always been dominated by microorganisms. Most genetic diversity exists in the form of microbes and if animals and plants were extinguished by cosmic bombardment, biology would reboot from reservoirs of this bounty. The numbers of microbes are staggering. Tens of millions of bacteria live in a crumb of soil. A drop of seawater contains 500,000 bacteria and tens of millions of viruses. The air is filled with microscopic fungal spores, and a hundred trillion bacteria swarm inside the human gut. Every macroscopic organism and every inanimate surface is coated with microbes. They grow around volcanoes and hydrothermal vents. They live in blocks of sea ice, in the deepest oceans, and thrive in ancient sediment on the seafloor. Microbes act as decomposers, recycling the substance of dead organisms. Others are primary producers, turning carbon dioxide into sugars using sunlight or by tapping chemical energy from hydrogen sulfide, ferrous iron, ammonia, and methane.

Bacterial infections are caused by decomposers that survive in living tissues. Airborne bacteria cause diphtheria, pertussis, tuberculosis, and meningitis. Airborne viruses cause influenza, measles, mumps, rubella, chickenpox, and the common cold. Hemorrhagic fevers caused by Ebola viruses are spread by direct contact with infected patients. Diseases transmitted by animal bites include bacterial plague, as the presumed cause of the Black Death, which killed 200 million people in the 14th century. Typhus spread by lice decimated populations of prisoners in concentration camps and refugees during the Second World War. Malaria, carried by mosquitos, massacres half a million people every year.

Contrary to the impression left by this list of infections, relatively few microbes are harmful and we depend on a lifelong cargo of single-celled organisms and viruses. The bacteria in our guts are essential for digesting the plant part of our diet and other bacteria and yeasts are normal occupants of healthy skin. The tightness of our relationship with microbes is illustrated by the finding that human DNA contains 100,000 fragments of genes that came from viruses. We are surprisingly microbial.

Agar kontaminaatio. Photo by Mädi. CC BY-SA 3.0 via Wikimedia Commons
Agar kontaminaatio. Photo by Mädi. CC BY-SA 3.0 via Wikimedia Commons

Missing the opportunity to learn something about microbiology is a mistake. The uninformed are likely to be left with a distorted view of biology in which they miscast themselves as the most important organisms. For example, “Sarah” is a significant manifestation of life from Sarah’s perspective, but her body is not the individual organism that she imagines, and nor, despite her talents, is she a major player in the ecology of the planet. Her interactions with microbes will include a healthy relationship with bacteria in her gut, bouts of influenza and other viral illnesses, and death in old age from an antibiotic-resistant infection. Sarah’s microbiology will continue after death with her decomposition by fungi. In happier times she will become an expert on Milton’s poetry, and delight students by reciting Lycidas through her tears, but she will never know a thing about microbiology. This is a pity. Learning about viruses that bloom in seawater and fungi that sustain rainforests would not have stopped her from falling in love with Milton.

Even brief consideration of microorganisms can be inspiring. A simple magnifying lens transforms the surface of rotting fruit into a hedgerow of glittering stalks topped with jet-black fungal spores. Microscopes take us deeper, to the slow revolution of the bright green globe of the alga Volvox as its beats its way through a drop of pond water. A greater number of microbes are quite dull things to look at and their appreciation requires greater imagination. Considering that our bodies are huge ecosystems supported by trillions of bacteria is a good place to start, and then we might realize that we fade from view against the grander galaxy of life on Earth. The science of microbiology is a marvel for our time.

Featured image credit: BglII-DNA complex By Gwilliams10. Public domain via Wikimedia Commons

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22. Meeting and mating with our ancient cousins

Two of the biggest scientific breakthroughs in paleoanthropology occurred in 2010. Not only had we determined a draft genome of an extinct Neandertal from bones that lay in the Earth for tens of thousands of years, but the genome from another heretofore unknown ancient human relative, dubbed the Denisovans, was also announced.

A one-hundred-year-old conundrum was finally answered: did we mate with Neandertals? It was now undeniable that modern humans, with all our modern features – our rounded craniums, prominent chins, gracile faces tucked beneath an enlarged forehead, and long, slender skeletons – had met and mated with both of these extinct ancient human-like beings. After comparison with the human genome, 2-4% of the genomes of all peoples outside Africa had been directly inherited from Neandertal ancestors. And, DNA from the Denisovans (named after the cave in southern Siberia where their bones were discovered) makes up 3% to 6% of the genomes of many peoples living in South East Asia (Philippines, Melanesians, Australian Aborigines).

We now believe that it is in the Levant, regions just east of the Mediterranean, where humans met and mated with Neandertals. Remains of Neandertals are well known from this region. When modern humans ventured out of Africa into the Levant approximately 50,000 years ago, they mated with Neandertals. When they later spread into South East Asia they mated with Denisovans, although mating probably occurred in other regions of Asia as well. We now have evidence suggesting the ancient Denisovans occupied a very large geographic distribution extending from Southern Siberia all the way to the South East Asian tropics. It is tantalizing that, other than their distinctive genomes and their somewhat robust-looking molars, we know close to nothing about what they looked like.

Neanderthal skull discovered in Gibraltar in 1848. Image credit: Creative Commons via AquilaGib.
Neanderthal skull discovered in Gibraltar in 1848. Photo by AquilaGib. CC BY-SA 3.0 via Wikimedia Commons.

With these discoveries, the notion that modern humans would hardly have interbred with such dim-witted, brutish, and bent-kneed Neandertals – a reputation that had long dogged Neandertals since French Paleontologist Marcellin Boule studied them – was now clearly out of the question. Indeed, more recent research into the skeleton and the cultural artifacts of Neandertals has demonstrated their sophisticated material cultures (stone tools, body ornament, and symbolic culture) and that their skeletons, rather than being “primitive,” were adapted for the cold and for rugged daily physical activities. Furthermore, the almost paradigmatically-held view of a strict replacement of ancient peoples in Eurasia by colonizing modern humans is now laid to rest. This view, popularized in the 1980s and 1990s, rested on comparisons between the minute mitochondrial genomes (much less than 1% of our full genomes) of humans and Neandertals. Full genomes, as you can see, tell us a fuller and more fascinating story.

These breakthroughs open a window of fresh air into the field of anthropology after decades of speculation. They are simultaneous with advancements in detecting the genetic bases of common chronic human diseases like hypertension, obesity, and diabetes. Yet even these diseases have been shaped by our evolutionary past. Genomes tell us that our species has undergone contractions in population size during the evolutionary past, which reduced the effectiveness of natural evolutionary constraints, and allowed damaging mutations to slip through the cracks to take root in our genome. This is a new view of disease informed by evolution as well as genomes.

We are also making base-by-base comparisons of our genome with those of chimpanzees, gorillas, orangutans, as well as genomes of other primates, allowing us to start to look for the genomic bases of our unique features – our large and complex brains, our complex cognition, and our use of spoken language. At the same time, we are learning the degree to which there is a genetic continuum between us and our primate relatives. Darwin presciently wrote in The Descent of Man and Selection in Relation to Sex that “the difference in mind between man and the higher animals, great as it is, certainly is one of degree and not of kind.” Today, we are realizing Darwin’s dream.

We are also uncovering details about how different human populations adapted to hot and cold climates, high altitudes, different diets, and to the various pathogens modern humans encountered as we colonized different regions of the world. A large project is already well-underway to collect thousands of genomes of modern peoples from different regions of the world. Comparing these genomes allows the search for ancient footprints left by positive selection (the type of natural selection that shapes our adaptations). Surprisingly, the different pathogens we encountered as we left Africa and spread into different environments appears to have made some of the largest footprints on our genome.

The genomic highway has an unchecked speed limit; we are experiencing a unique problem where data is pouring in faster than it can be fully analyzed. Each new issue of our scientific journals is ripe with new, exciting discoveries unlocking intriguing secrets of our ancestry.

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23. Looking for Tutankhamun

Poor old king Tut has made the news again – for all the wrong reasons, again.

In a documentary that aired on the BBC two weeks ago, scientists based at the EURAC-Institute for Mummies and the Iceman unveiled a frankly hideous reconstruction of Tutankhamun’s mummy, complete with buck teeth, a sway back, Kardashian-style hips, and a club foot. They based it on CT-scans of the mummy from 2005 and their own research, claiming to have identified a host of genetic disorders and physical deformities suffered by the boy-king, who died around age 19 some 3,300 years ago.

The English-language newspaper Ahram Online has aired the views of three Egyptian Egyptologists who are just as shocked by the reconstruction as many television viewers were. There are old and understandable sensitivities here: Western scientists have been poking around Egyptian mummies for more than 200 years, while the discovery of Tutankhamun’s tomb in 1922 coincided with the birth of an independent Egyptian nation after decades of European colonialism. The ensuing tussle between excavator Howard Carter and the government authorities, over where the tomb finds would end up (Cairo won, and rightly so), highlighted deep-seated tensions about who ‘owned’ ancient Egypt, literally and figuratively. It’s safe to say that the last century has seen king Tut more involved in politics than he ever was in his own lifetime.

Most Egyptologists can readily debunk the ‘evidence’ presented by the EURAC team – if we weren’t so weary of debunking television documentaries already. (why do the ancient Romans get academic royalty like Mary Beard, while the ancient Egyptians get the guy from The Gadget Show?). What’s fascinating is how persistent – and how misguided – lurid interest in the dead bodies of ancient Egyptians is, not to mention the wild assumptions made about the skilled and stunning art this culture produced. The glorious gold mask, gilded shrines and coffins, weighty stone sarcophagus, and hundreds of other objects buried with Tutankhamun were never meant to show us a mere human, but to manifest the razzle-dazzle of a god-king.

Around the time of Tutankhamun’s reign, artists depicted the royal family and the gods with almond eyes, luscious lips, and soft, plump bodies. These were never meant to be true-to-life images, as if the pharaoh and his court were posting #nomakeupselfie snaps on Twitter. Each generation of artists developed a style that was distinctive to a specific ruler, but which also linked him to a line of ancestors, emphasizing the continuity and authority of the royal house. The works of art that surrounded Tutankhamun in life, and in death, were also deeply concerned with a king’s unique responsibilities to his people and to the gods.

Death mask of Tutankhamun, by. CC-BY-NC-SA-2.0 via Flickr.
Death mask of Tutankhamun, by ironmanixs. CC-BY-NC-SA-2.0 via Flickr.

All the walking sticks buried in the tomb – more than 130 of them, one of which Carter compared to Charlie Chaplin’s ubiquitous prop – emphasize the king’s status at the pinnacle of society (nothing to do with a limp). The chariots were luxury items (quite macho ones, at that), and Tutankhamun’s wardrobe was the haute couture of its day, with delicate embroidery and spangly sequins. Much of the tomb was taken up with deeply sacred objects, too: guardian statues at the doorways, magic figures bricked into the walls, and two dozen bolted shrines protecting wrapped statues of the king and various gods. Not to mention the shrines, sarcophagus, and coffins that held the royal mummy – a sacred object in itself, long before science got a hold of it.

As for the diseases and deformities Tutankhamun is said to have suffered? Allegations of inbreeding don’t add up: scholars have exhaustively combed through the existing historical sources that relate to Tutankhamun (lots and lots of rather dry inscriptions, I’m afraid), and as yet there is no way to identify his biological parents with any certainty. Don’t assume that DNA is an easy answer, either. Not only do we not know the identity of almost any of the ‘royal’ mummies that regularly do the rounds on TV programmes, but also the identification of DNA from ancient mummies is contested – it simply doesn’t survive in the quantity or quality that DNA amplification techniques require. Instead, many of the ‘abnormal’ features of Tutankhamun’s mummy, like the supposed club foot and damage to the chest and skull, resulted from the mummification process, as research on other mummies has surmised. Embalming a body to the standard required for an Egyptian king was a difficult and messy task, left to specialist priests. What mattered just as much, if not more, was the intricate linen wrapping, the ritual coating of resin, and the layering of amulets, shrouds, coffins, and shrines that Carter and his team had to work through in order to get to the fragile human remains beneath.

The famous mummy mask and spectacular coffins we can see in the Museum of Egyptian Antiquities in Cairo today, or in copious images online, should stop us in our tracks with their splendour and skill. That’s what they were meant to do, for those few people who saw them and for the thousands more whose lives and livelihoods depended on the king. But they should also remind us of how they got there: the invidious colonial system under which archaeology flourished in Egypt, for a start, and the thick resin that had to be hammered off so that the lids could be opened and the royal mummy laid bare. Did king Tut have buck teeth, waddle like a duck, drag race his chariot? Have a look at that mask: do you think we’ve missed the point? Like so many modern engagements with the ancient past, this latest twist in the Tutankhamun tale says more about our times than his.

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24. Illuminating the drama of DNA: creating a stage for inquiry

Many bioethical challenges surround the promise of genomic technology and the power of genomic information — providing a rich context for critically exploring underlying bioethical traditions and foundations, as well as the practice of multidisciplinary advisory committees and collaborations. Controversial issues abound that call into question the core values and assumptions inherent in bioethics analysis and thus necessitates interprofessional inquiry. Consequently, the teaching of genomics and contemporary bioethics provides an opportunity to re-examine our disciplines’ underpinnings by casting light on the implications of genomics with novel approaches to address thorny issues — such as determining whether, what, to whom, when, and how genomic information, including “incidental” findings, should be discovered and disclosed to individuals and their families, and whose voice matters in making these determinations particularly when children are involved.

One creative approach we developed is narrative genomics using drama with provocative characters and dialogue as an interdisciplinary pedagogical approach to bring to life the diverse voices, varied contexts, and complex processes that encompass the nascent field of genomics as it evolves from research to clinical practice. This creative educational technique focuses on inherent challenges currently posed by the comprehensive interrogation and analysis of DNA through sequencing the human genome with next generation technologies and illuminates bioethical issues, providing a stage to reflect on the controversies together, and temper the sometimes contentious debates that ensue.

As a bioethics teaching method, narrative genomics highlights the breadth of individuals affected by next-gen technologies — the conversations among professionals and families — bringing to life the spectrum of emotions and challenges that envelope genomics. Recent controversies over genomic sequencing in children and consent issues have brought fundamental ethical theses to the stage to be re-examined, further fueling our belief in drama as an interdisciplinary pedagogical approach to explore how society evaluates, processes, and shares genomic information that may implicate future generations. With a mutual interest in enhancing dialogue and understanding about the multi-faceted implications raised by generating and sharing vast amounts of genomic information, and with diverse backgrounds in bioethics, policy, psychology, genetics, law, health humanities, and neuroscience, we have been collaboratively weaving dramatic narratives to enhance the bioethics educational experience within varied professional contexts and a wide range of academic levels to foster interprofessionalism.

1024px-A-DNA,_B-DNA_and_Z-DNA
From left to right, the structures of A-, B-, and Z-DNA by Zephyris (Richard Wheeler). CC-BY-SA-3.0 from Wikimedia Commons.

Dramatizations of fictionalized individual, familial, and professional relationships that surround the ethical landscape of genomics create the potential to stimulate bioethical reflection and new perceptions amongst “actors” and the audience, sparking the moral imagination through the lens of others. By casting light on all “the storytellers” and the complexity of implications inherent with this powerful technology, dramatic narratives create vivid scenarios through which to imagine the challenges faced on the genomic path ahead, critique the application of bioethical traditions in context, and re-imagine alternative paradigms.

Building upon the legacy of using case vignettes as a clinical teaching modality, and inspired by “readers’ theater”, “narrative medicine,” and “narrative ethics” as approaches that helped us expand the analyses to implications of genomic technologies, our experience suggests similar value for bioethics education within the translational research and public policy domain. While drama has often been utilized in academic and medical settings to facilitate empathy and spotlight ethical and legal controversies such as end-of-life issues and health law, to date there appears to be few dramatizations focusing on next-generation sequencing (NGS) in genomic research and medicine.

We initially collaborated on the creation of a short vignette play in the context of genomic research and the informed consent process that was performed at the NHGRI-ELSI Congress by a geneticist, genetic counselor, bioethicists, and other conference attendees. The response by “actors” and audience fueled us to write many more plays of varying lengths on different ethical and genomic issues, as well as to explore the dialogues of existing theater with genetic and genomic themes — all to be presented and reflected upon by interdisciplinary professionals in the bioethics and genomics community at professional society meetings and academic medical institutions nationally and internationally.

Because narrative genomics is a pedagogical approach intended to facilitate discourse, as well as provide reflection on the interrelatedness of the cross-disciplinary issues posed, we ground our genomic plays in current scholarship and ensure that it is accurate scientifically as well as provide extensive references and pose focused bioethics questions which can complement and enhance the classroom experience.

In a similar vein, bioethical controversies can also be brought to life with this approach where bioethics reaching incorporates dramatizations and excerpts from existing theatrical narratives, whether to highlight bioethics issues thematically, or to illuminate the historical path to the genomics revolution and other medical innovations from an ethical perspective.

Varying iterations of these dramatic narratives have been experienced (read, enacted, witnessed) by bioethicists, policy makers, geneticists, genetic counselors, other healthcare professionals, basic scientists, bioethicists, lawyers, patient advocates, and students to enhance insight and facilitate interdisciplinary and interprofessional dialogue.

Dramatizations embedded in genomic narratives illuminate the human dimensions and complexity of interactions among family members, medical professionals, and others in the scientific community. By facilitating discourse and raising more questions than answers on difficult issues, narrative genomics links the promise and concerns of next-gen technologies with a creative bioethics pedagogical approach for learning from one another.

Heading image: Andrzej Joachimiak and colleagues at Argonne’s Midwest Center for Structural Genomics deposited the consortium’s 1,000th protein structure into the Protein Data Bank. CC-BY-SA-2.0 via Wikimedia Commons.

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25. The Man in the Monkeynut Coat and the men in the yellow jerseys

By Kersten Hall


It is a safe bet that the name of Pierre Rolland rings very few bells among the British public. In 2012, Rolland, riding for Team Europcar finished in eighth place in the overall final classifications of the Tour de France whilst Sir Bradley Wiggins has since become a household name following his fantastic achievement of being the first British person ever to win the most famous cycle race in the world.

In the world of sport, we remember a winner. But the history of science is often also described in similar terms – as a tale of winners and losers racing to the finish line. Nowhere is this more true than in the story of the discovery of the structure of DNA. When James Watson’s book, The Double Helix was published in 1968, it depicted science as a frantic and often ruthless race in which the winner clearly took all. In Watson’s account, it was he and his Cambridge colleague Francis Crick who were first to cross the finish line, with their competitors Rosalind Franklin at Kings College, London and Linus Pauling at Caltech, Pasadena trailing in behind.

There is no denying the importance of Watson and Crick’s achievement: their double-helical model of DNA not only answered fundamental questions in biology such as how organisms pass on hereditary traits from one generation to the next but also heralded the advent of genetic engineering and the production of vital new medicines such as recombinant insulin. But it is worth asking whether this portrayal of science as a breathless race to the finish line with only winners and losers, is necessarily an accurate one. And perhaps more importantly, does it actually obscure the way that science really works?

William Astbury. Reproduced with the permission of Leeds University Library

William Astbury. Reproduced with the permission of Leeds University Library

To illustrate this point, it is worth remembering that Watson and Crick obtained a vital clue to solving the double-helix thanks to a photograph taken by the crystallographer Rosalind Franklin. Labelled in her lab notes as ‘Photo 51′, it showed a pattern of black spots arranged in the shape of a cross, formed when X-rays were diffracted by fibres of DNA. The effect of this image on Watson was dramatic. The sight of the black cross, he later said, made his jaw drop and pulse race for he knew that this pattern could only arise from a molecule that was helical in shape.

In recognition of its importance in the discovery of the double-helical structure of DNA, a plaque on the wall outside King’s College, London where Franklin worked now hails ‘Photo 51‘ as being ‘one of the world’s most important photographs’. Yet curiously, neither Watson nor Franklin had been the first to observe this striking cross pattern. For almost a year earlier, the physicist William Astbury working in his lab at Leeds had obtained an almost identical X-ray diffraction pattern of DNA.

Yet despite obtaining this clue that would prove to be so vital to Watson and Crick, Astbury never solved the double-helical structure himself and whilst the Cambridge duo went to win the Nobel Prize for their work, Astbury remains largely forgotten.

But to dismiss him as a mere ‘also-ran’ in the race for the double-helix would be both harsh and hasty: the questions that Astbury was asking and the aims of his research were subtly but significantly different to those of Watson and Crick. The Cambridge duo were solely focussed on DNA, whereas Astbury felt that by studying a wide range of biological fibres from wool to bacterial flagella, he might uncover some deep common theme based on molecular shape that could unify the whole of biology. It was this emphasis on the molecular shape of fibres and how these shapes could change that formed his core definition of the new science of ‘molecular biology’ which he helped to found and popularise, and one that has had a profound impact on modern biology and medicine.

On 5th July this year, Leeds will host ‘Le Grand Depart’ – the start of the 2014 Tour de France. As the contestants begin to climb the hills of Yorkshire each will no doubt harbour dreams of wearing the coveted yellow jersey and all will have their sights firmly fixed on crossing the same ultimate finishing line. At first sight scientific discovery may also appear to be a race towards a single finish line, but in truth it is a much more muddled affair rather like a badly organised school sports day in which several races all taking place in different directions and over different distances became jumbled together. For this reason it makes little sense to think of Astbury as having ‘lost’ the race for DNA to Watson and Crick. That Leeds was chosen to host the start of the 2014 Tour de France, is an honour for which the city can take pride, but in the life and work of William Astbury it also has a scientific heritage of which it can be equally proud.

Kersten Hall is graduated from St. Anne’s College, Oxford with a degree in biochemistry, before embarking on a PhD at the University of Leeds using molecular biology to study how viruses evade the human immune system. He then worked as a Research Fellow in the School of Medicine at Leeds during which time he developed a keen interest in the historical and philosophical roots of molecular biology. He is now Visiting Fellow in the School of Philosophy, Religion and History of Science, where his research focuses on the origins of molecular biology and in particular the role of the pioneering physicist William T. Astbury and the work of Sir William and Lawrence Bragg. He is the author of The Man in the Monkeynut Coat.

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Image credit: William Astbury, Reproduced with the permission of Leeds University Library

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