By: Sarah McKenna,
on 4/22/2016
The man doing a spot of gardening cleaning out his fishpond in Europe, the woman who becomes unwell after giving birth in rural India, the child with pneumonia in Rwanda, and the senior citizen who develops diverticulitis in Singapore – the triggers are different but they all die from the same disease process: sepsis.
The post Sepsis: What we need to know now appeared first on OUPblog.
By: Hannah Paget,
on 2/8/2016
Over two years ago I wrote that “new viruses are constantly being discovered... Then something comes out of the woodwork like SARS which causes widespread panic”. Zika virus infection bids fair to repeat the torment. On 28 January 2016 the BBC reported that the World Health Organization had set up a Zika “emergency team” as a result of the current explosive pandemic.
The post Another unpleasant infection: Zika virus appeared first on OUPblog.
By: Connie Ngo,
on 1/22/2016
Though caused by microscopic agents, infectious diseases have played an outsized role in human history. They have shaped societies, lent us words and metaphors, and turned the tide of wars. Humans have eliminated some diseases, but others continue to plague us. In this quiz, find out if confusion is contagious or if you’re immune to the challenge.
The post Name that plague! [quiz] appeared first on OUPblog.
By: Joe Couling,
on 8/28/2015
This summer intrepid travelers everywhere are strapping on backpacks, dousing themselves in mosquito spray, and getting their inoculations -- ready to embark on journeys that will take them into contact with some of the most virulent viruses and nastiest bacteria on the planet. Even those of us who aren’t going off the beaten track may end up in close quarters with microbes we’d rather not befriend. Explore some of the most common infectious diseases around the globe and how to identify them in this infographic.
The post Common infectious diseases contracted by travellers worldwide [infographic] appeared first on OUPblog.
By: ChloeF,
on 12/26/2014
Microbiology should be part of everyone’s educational experience. European students deserve to know something about the influence of microscopic forms of life on their existence, as it is at least as important as the study of the Roman Empire or the Second World War. Knowledge of viruses should be as prominent in American high school curricula as the origin of the Declaration of Independence. This limited geographic compass reflects the fact that the science of microbiology is a triumph of Western civilization, but the educational significance of the field is a global concern. We cannot understand life without an elementary comprehension of microorganisms.
Appreciation of the microbial world might begin by looking at pond water and pinches of wet soil with a microscope. Precocious children could be encouraged in this fashion at a very early age. Deeper inquiry with science teachers would build a foundation of knowledge for teenagers, before the end of their formal education or the pursuit of a university degree in the humanities.
Earth has always been dominated by microorganisms. Most genetic diversity exists in the form of microbes and if animals and plants were extinguished by cosmic bombardment, biology would reboot from reservoirs of this bounty. The numbers of microbes are staggering. Tens of millions of bacteria live in a crumb of soil. A drop of seawater contains 500,000 bacteria and tens of millions of viruses. The air is filled with microscopic fungal spores, and a hundred trillion bacteria swarm inside the human gut. Every macroscopic organism and every inanimate surface is coated with microbes. They grow around volcanoes and hydrothermal vents. They live in blocks of sea ice, in the deepest oceans, and thrive in ancient sediment on the seafloor. Microbes act as decomposers, recycling the substance of dead organisms. Others are primary producers, turning carbon dioxide into sugars using sunlight or by tapping chemical energy from hydrogen sulfide, ferrous iron, ammonia, and methane.
Bacterial infections are caused by decomposers that survive in living tissues. Airborne bacteria cause diphtheria, pertussis, tuberculosis, and meningitis. Airborne viruses cause influenza, measles, mumps, rubella, chickenpox, and the common cold. Hemorrhagic fevers caused by Ebola viruses are spread by direct contact with infected patients. Diseases transmitted by animal bites include bacterial plague, as the presumed cause of the Black Death, which killed 200 million people in the 14th century. Typhus spread by lice decimated populations of prisoners in concentration camps and refugees during the Second World War. Malaria, carried by mosquitos, massacres half a million people every year.
Contrary to the impression left by this list of infections, relatively few microbes are harmful and we depend on a lifelong cargo of single-celled organisms and viruses. The bacteria in our guts are essential for digesting the plant part of our diet and other bacteria and yeasts are normal occupants of healthy skin. The tightness of our relationship with microbes is illustrated by the finding that human DNA contains 100,000 fragments of genes that came from viruses. We are surprisingly microbial.
Missing the opportunity to learn something about microbiology is a mistake. The uninformed are likely to be left with a distorted view of biology in which they miscast themselves as the most important organisms. For example, “Sarah” is a significant manifestation of life from Sarah’s perspective, but her body is not the individual organism that she imagines, and nor, despite her talents, is she a major player in the ecology of the planet. Her interactions with microbes will include a healthy relationship with bacteria in her gut, bouts of influenza and other viral illnesses, and death in old age from an antibiotic-resistant infection. Sarah’s microbiology will continue after death with her decomposition by fungi. In happier times she will become an expert on Milton’s poetry, and delight students by reciting Lycidas through her tears, but she will never know a thing about microbiology. This is a pity. Learning about viruses that bloom in seawater and fungi that sustain rainforests would not have stopped her from falling in love with Milton.
Even brief consideration of microorganisms can be inspiring. A simple magnifying lens transforms the surface of rotting fruit into a hedgerow of glittering stalks topped with jet-black fungal spores. Microscopes take us deeper, to the slow revolution of the bright green globe of the alga Volvox as its beats its way through a drop of pond water. A greater number of microbes are quite dull things to look at and their appreciation requires greater imagination. Considering that our bodies are huge ecosystems supported by trillions of bacteria is a good place to start, and then we might realize that we fade from view against the grander galaxy of life on Earth. The science of microbiology is a marvel for our time.
Featured image credit: BglII-DNA complex By Gwilliams10. Public domain via Wikimedia Commons
The post Discovering microbiology appeared first on OUPblog.
By: Nicola,
on 12/1/2011
On World AIDS Day 2011, we speak with Dr Martin S. Hirsch, MD, FIDSA to find out the latest news on the global fight against AIDS. Dr. Hirsch is editor-in-chief of The Journal of Infectious Diseases, professor of medicine at Harvard Medical School, professor of infectious diseases and immunology at the Harvard School of Public Health, and a physician at Massachusetts General Hospital. – Nicola
Q: Thirty years after the first reports of AIDS, why is HIV/AIDS research still important?
A: Although we have made enormous progress in developing effective combination antiretroviral therapies to control HIV infection, we have been far less successful in preventing infection. Thus, in the US, as well as in the rest of the world, there are more people living with HIV infection today than ever before; worldwide, this number is over 30 million. Many individuals who are infected do not know that they are and, thus, they continue to spread virus to contacts by sexual contact, needle sharing, or mother-to-child transmission. We are not near having an effective preventative HIV vaccine, nor is a cure for those already infected on the immediate horizon. The risk of emerging drug-resistant viruses is also always with us. For all these reasons and more, it is essential that research efforts continue until we can say that HIV has been eradicated or is no longer a public health problem in the world.
Q: What notable important discoveries or research findings have there been in the field recently?
A: In my view, the most notable research advances in the field recently have been in efforts to prevent new HIV infections by using treatment as prevention and pre-exposure prophylaxis. Studies published this year by Myron Cohen and colleagues have shown in placebo-controlled studies that by treating HIV-infected members of discordant couples (one infected, one not), new infections can be reduced by up to 96 percent. This emphasizes the need for early recognition of infections and early treatment. It has also been established that pre-exposure prophylaxis with antiretroviral drugs can reduce transmission in high-risk populations, whether they be heterosexual or men who have sex with men. Pre-exposure prophylactic regimens have taken the form of oral therapy or topical administration of vaginal microbicides. The challenge now is to find ways to implement these strategies worldwide to prevent new infections in cost-effective ways.
Q: What should the public take away from these findings?
A: The public should be aware that only by early recognition of infection can we reduce the scourge of continued HIV transmission and disease. The US Centers for Disease Control and Prevention and other organizations have indicated the need for more routine testing of all populations who enter medical care in the US, and gradually our states and other public health authorities are implementing these suggestions. Nevertheless, there are still thousands of individuals in the US and millions in the world who do not know they are infected and who continue to spread virus. The public should insist on more HIV testing with appropriate measures to protect confidentiality among those tested. It is also critical that efforts to make effective therapies available to those in need not be curtailed in these times of budget stringency. Cuts at this time would reap bitter harvests in years to come.
Q: What do you see as the priority areas for future HIV/AIDS research? Where will the next great advances be?
A: There are several priority areas for HIV research in the years ahead. These include:
- Continued efforts to develop safe and effective prophylacti
By: Rebecca,
on 5/6/2009
Leslie Francis is Professor of Philosophy, Professor of Law, and Adjunct Professor of Internal Medicine in the Division of Medical Ethics and Humanities at the University of
Utah. Together with Margaret P. Battin, Jay A. Jacobson and Charles B. Smith, she wrote The Patient as Victim and Vector: Ethics and Infectious Disease which explores how traditional and new issues in clinical medicine, research, public health, and health policy might look different if infectious disease were treated as central. The authors argue that both practice and policy must recognize that a patient with a communicable infectious disease is not only a victim of that disease, but also a potential vector- someone who may transmit an illness that will sicken or kill others. In the post below Francis looks specifically at the H1N1 outbreak.
The recent outbreak of H1N1 influenza in Mexico has been greeted with great concern to prevent spread. Trips have been cancelled, travelers have been quarantined, schools have been closed, and sporting events will go uncontested. Preventing spread is important, to be sure, especially of a novel agent with unknown infectivity and lethality. But there is a down side to all the worry about spread: it encourages us to think of each other as vectors, sources of disease to be feared.
We are all vectors or potential; that’s a biological fact. But it’s only one side of our biology. We’re “way-station” selves, breeding grounds and launching pads for literally trillions of microorganisms, all the time—but we’re also recipients of them too. In short: we’re all victims,
just as we are vectors. We live in a state of perpetual uncertainty about whether we’re victims, vectors, or both, at any given time.
As we are caught up in the fear of pandemic spread, we need to remember our victim-side, too. There’s been some discussion of this in the press reports: stories of empty hotels, the cancelled U-17 Concacaf tournament, travelers quarantined in airports, workers without
childcare, or pigs slaughtered unnecessarily in Egypt. But there have been no comprehensive reminders that people stricken with the flu or suspected as vectors are victims as well and in need of support: medical care if they are ill, economic consideration if their livelihoods are
lost, and just plain concern when events that are important to them must be cancelled to enforce the social distancing that is hoped to prevent spread.
In pandemic planning, much effort has been devoted to preventing disease spread. We are seeing the importance of these measures in the current situation. As fears wane, or refocus on later, perhaps more virulent phases of an epidemic or on future emergences of new infectious diseases, however, it is equally important for us to plan for victims and to ask what we owe them. Such planning efforts may be particularly important to encourage the sharing of epidemiological data in the future, if the economic impacts on Mexico are dire and left unattended, where data sharing and international cooperation is crucial in disease control. That’s a prudential imperative, but it’s an ethical one, too. After all, we’re all in this together,working together not only to prevent the spread of infectious disease but also to mitigate the impact of disease where it strikes.
