How can an element be lost? Scientists, and the general public, have always thought of them as being found, or discovered. However, more elements have been “undiscovered” than discovered, more “lost” than found.Add a Comment
How can an element be lost? Scientists, and the general public, have always thought of them as being found, or discovered. However, more elements have been “undiscovered” than discovered, more “lost” than found.Add a Comment
One of the most interesting developments in the history of chemistry has been the way in which theories of valency have evolved over the years. We are rapidly approaching the centenary of G.N. Lewis’ 1916 article in which he proposed the simple idea that a covalent bond consists of a shared pair of electrons.Add a Comment
American consumers have increased their purchases of artisanal foods in recent years. Grant McCracken, an anthropologist who reports on American culture and business, identifies ten concepts that the artisanal movement is composed of and driven by. These include preferences for things that are handmade, on the human scale, relatively raw and untransformed, unbranded, personalized [...]
The post What’s the difference between artisanal and mass-produced cheese? appeared first on OUPblog.Add a Comment
One of the central concepts in chemistry consists in the electronic configuration of atoms. This is equally true of chemical education as it is in professional chemistry and research. If one knows how the electrons in an atom are arranged, especially in the outermost shells, one immediately understands many properties of an atom...Add a Comment
The periodic system, which Dmittri Ivanovich Mendeleev presented to the science community in the fall of 1870, is a well-established tool frequently used in both pedagogical and research settings today. However, early reception of Mendeleev’s periodic system, particularly from 1870 through 1930, was mixed.
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Dmitri Mendeleev believed he was a great scientist and indeed he was. He was not actually recognized as such until his periodic table achieved worldwide diffusion and began to appear in textbooks of general chemistry and in other major publications. When Mendeleev died in February 1907, the periodic table was established well enough to stand on its own and perpetuate his name for upcoming generations of chemists.
The man died, but the myth was born.
Mendeleev as a legendary figure grew with time, aided by his own well-organized promotion of his discovery. Well-versed in foreign languages and with a sort of overwhelming desire to escape his tsar-dominated homeland, he traveled the length and breadth of Europe, attending many conferences in England, Germany, Italy, and central Europe, his only luggage seemingly his periodic table.
Mendeleev had succeeded in creating a new tool that chemists could use as a springboard to new and fascinating discoveries in the fields of theoretical, mineral, and general chemistry. But every coin has two faces, even the periodic table. On the one hand, it lighted the path to the discovery of still missing elements; on the other, it led some unfortunate individuals to fall into the fatal error of announcing the discovery of false or spurious supposed new elements. Even Mendeleev, who considered himself the Newton of the chemical sciences, fell into this trap, announcing the discovery of imaginary elements that presently we know to have been mere self-deception or illusion.
It probably is not well-known that Mendeleev had predicted the existence of a large number of elements, actually more than ten. Their discoveries were sometimes the result of lucky guesses (like the famous cases of gallium, germanium, and scandium), and at other times they were erroneous. Historiography has kindly passed over the latter, forgetting about the long line of imaginary elements that Mendeleev had proposed, among which were two with atomic weights lower than that of hydrogen, newtonium (atomic weight = 0.17) and coronium (Atomic weight = 0.4). He also proposed the existence of six new elements between hydrogen and lithium, whose existence could not but be false.
Mendeleev represented a sort of tormented genius who believed in the universality of his creature and dreaded the possibility that it could be eclipsed by other discoveries. He did not live long enough to see the seed that he had planted become a mighty tree. He fought equally, with fierce indignation, the priority claims of others as well as the advent of new discoveries that appeared to menace his discovery.
In the end, his table was enduring enough to accommodate atomic number, isotopes, radioisotopes, the noble gases, the rare earth elements, the actinides, and the quantum mechanics that endowed it with a theoretical framework, allowing it to appear fresh and modern even after a scientific journey of 145 years.
Image: Nursery of new stars by NASA, Hui Yang University of Illinois. Public domain via Wikimedia Commons.
This is the second post in our latest regular OUPblog column: SciWhys. Every month OUP editor and author Jonathan Crowe will be answering your science questions. Got a burning question about science that you’d like answered? Just email it to us, and Jonathan will answer what he can. Today: What are genes and genomes?
I described in my last blog post how DNA acts as a store of biological information – information that serves as a set of instructions that direct our growth and function. Indeed, we could consider DNA to be the biological equivalent of a library – another repository of information with which we’re all probably much more familiar. The information we find in a library isn’t present in one huge tome, however. Rather, it is divided into discrete packages of information – namely books. And so it is with DNA: the biological information it stores isn’t captured in a single, huge molecule, but is divided into separate entities called chromosomes – the biological equivalent of individual books in a library.
I commented previously that DNA is composed of a long chain of four building blocks, A, C, G, and T. Rather than existing as an extended chain (like a stretched out length of rope), the DNA in a chromosome is tightly packaged. In fact, if stretched out (like our piece of rope), the DNA in a single chromosome would be around 2-8 cm long. Yet a typical chromosome is just 0.00002–0.002 cm long: that’s between 1000 and 100,000 times shorter than the unpackaged DNA would be. This packaging is quite the feat of space-saving efficiency.
Let’s return to our imaginary library of books. The information in a book isn’t presented as one long uninterrupted sequence of words. Rather, the information is divided into chapters. When we want to find out something from a book – to extract some specific information from it – we don’t read the whole thing cover-to-cover. Instead, we may just read a single chapter. In a fortuitous extension of our analogy, the same is true of information retrieval from chromosomes. The information captured in a single chromosome is stored in discrete ‘chunks’ (just as a book is divided into chapters), and these chunks can be read separately from one another. These ‘chunks’ – these discrete units of information – are what we call ‘genes’. In essence, one gene contains one snippet of biological information.
I’ve just likened chromosomes to books in a library. But is there a biological equivalent of the library itself? Well, yes, there is. Virtually every cell in the human body (with specific exceptions) contains 46 chromosomes – 23 from each of its parents. All of the genes found in this ‘library’ of chromosomes are collectively termed the ‘genome’. Put another way, a genome is a collection of all the genes found in a particular organism.
Different organisms have different-sized genomes. For example, the human genome comprises around 20,000-25,000 genes; the mouse genome, with 40 chromosomes, comprises a similar number of individual genes. However, the bacterium H. influenzae has just a single chromosome, containing around 1700 genes.
It is not just the number of genes (and chromosomes) in the genome that varies between organisms: the long stretches of DNA making up the genomes of different organisms have different sequences (and so store different information). These differences make sense, particularly if we imagine the genome of an organism to represent the ‘recipe’ for that organism: a human is quite a different organism from a mouse, so we would expect the instructions that direct the growth and function of the two organisms to differ.
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This is the third post in our latest regular OUPblog column: SciWhys. Every month OUP editor and author Jonathan Crowe will be answering your science questions. Got a burning question about science that you’d like answered? Just email it to us, and Jonathan will answer what he can. Today: How is the information in a gene used by a cell?
In my last two posts I’ve introduced the notion that DNA acts as a store of biological information; this information is stored in a series of chromosomes, each of which are divided into a number of genes. Each gene in turn contains one ‘snippet’ of biological information. But how are these genes actually used? How is the information stored in these genes actually extracted to do something useful (if ‘useful’ isn’t too flippant a term for something that the very continuation of life depends upon).
Many (but not all) genes act as recipes for a family of biological molecules called proteins: they literally tell the cell what the ingredients for a particular protein are, and how they should be combined to create the protein itself. (Proteins have a range of essential roles in the human body. Some act as building materials for different components of the body, such as the keratin we find in our hair and nails. Others act as molecular transporters: haemoglobin, which is found in our red blood cells, carries oxygen from our lungs to other parts of the body. A family of proteins called the enzymes are arguably the most important, however. Enzymes cajole different chemicals in our body into reacting with one another. Without enzymes, our bodies would be unable to generate energy from the food we eat (and you’d not be reading this blog post).)
So, somehow, the information stored in a DNA molecule is deciphered by the cell and used as the recipe for a protein. But how?
To answer this question, let’s take a journey inside the cell. We can imagine a cell to be like a factory, but one that has been divided into a series of physically separated compartments. Unlike a factory filled with air, a cell is filled with a jelly-like fluid called the cytoplasm, which surrounds the various compartments enclosed within it. In an earlier post I likened a genome to a biological library. And, inside the cell, this library is stored within a particular compartment called the nucleus.
I mentioned earlier that genes often act as recipes for proteins. But here comes a bit of a quandary: chromosomes – and the genes they contain – are locked away inside the cell’s nucleus. By contrast, proteins are manufactured by the cell in the cytoplasm, outside of the nucleus. So, for the genetic information to be used, it has to get out of nucleus and into the cytoplasm. How does this happen? Well, if we’re in a library with a book that contains information we really need, but we’re unable to take the book out of the library, we might make a photocopy of the page that holds the information we’re after. To get the information it needs out of the nucleus and into the cytoplasm the cell does something remarkably similar. The chromosome containing the gene of interest has to stay inside the nucleus, so the cell makes a copy of the gene – and that copy is then transported to where it is to be used: out of the nucleus and into the cytoplasm.
The copy of the gene generated during this cellular photocopying is made not of DNA but of a close cousin called RNA. RNA is made of three of the same building blocks as DNA – A, C and G. Instead of the T found in DNA, however, RNA uses a different block represented by the letter U (for ‘uracil’). Despite thisAdd a Comment
This is the latest post in our regular OUPblog column SciWhys. Every month OUP editor and author Jonathan Crowe will be answering your science questions. Got a burning question about science that you’d like answered? Just email it to us, and Jonathan will answer what he can. Today: what is gene mutation?
In my last three posts I’ve introduced you to the world of biological information, taking you from the storage of biological information in libraries called genomes, which house information in individual books called chromosomes (themselves divided into chapters called genes), to the way the cell makes use of that stored information to manufacture the molecular machines called proteins.
But what happens when the storage of information goes wrong? If we’re reading a recipe and that recipe contains a mistake, chances are that the end-result of our culinary endeavour won’t end up as it should. And so it is at the level of cells. If the information the cell is using is somehow wrong, the end result will also be wrong – sometimes with catastrophic results.
I’ve mentioned in previous posts how biological information is captured by the sequence of the building block ‘letters’ from which DNA is constructed. The sequence of letters is ultimately deciphered by a molecular machine called the ribosome, which reads the sequence of letters in sets of three, and uses each trio to determine which amino acid – the building block of proteins – should be used next in its mission to construct a particular protein. It should come as no surprise that, if the recipe for the protein is changed – if the sequence of DNA ‘letters’ is altered – the protein that is manufactured will probably contain errors as a result. And if a protein contains errors, it won’t be able to function correctly, just as flat-packed furniture will end up being decidedly wobbly if you construct it from the wrong parts.
Imagine a snippet of DNA has the sequence GGTGCTAAG. The ribosome would ‘read’ this sequence, and would use it as the recipe for building a chain of three amino acids: Glycine-Alanine-Lysine. Now imagine that we alter just one letter in our original sequence so that it becomes GGTCCTAAG. All we’ve done is swap a G for a C at the fourth position in the DNA sequence. However, this change is sufficient to affect the composition of the protein that is produced when the sequence is deciphered: the ribosome will now build a chain with the composition Glycine-Proline-Lysine.
Surely such a small change won’t actually cause significant problems in a cell, though. Right? Wrong. Amazingly (and perhaps unnervingly) the tiniest error can have really quite significant consequences.
Let’s take just one example. Sickle cell anaemia is a condition that affects the red blood cells of humans. Red blood cells fulfil the essential role of transporting oxygen from our lungs to all the living cells of our body: they continually circulate through our arteries and veins, shuttling oxygen from one place to another. A healthy red blood cell looks a bit like a ring doughnut (though it doesn’t actually have a hole right through the middle); by contrast, the red blood cells of individuals with sickle cell anaemia become warped into crescent-like shapes (like a sickle, the grass-cutting tool, after which the disease is named). These sickle cells no longer pass freely through our arteries and veins. Instead, they tend to get entangled with each other. As a result, the flow of oxygen round the body is impeded, andAdd a Comment
I wonder how many times students have been directed to complete a table for homework or on an exam. Chemists have an incomplete table that they are trying to complete: the Periodic Table of the Elements, or the Periodic Table, for short. Uranium, element number 92 is the last naturally occurring element in the Periodic Table. Elements beyond number 92, called the transuranium elements, have all been produced in laboratories. The first transuranium element, neptunium (#93) was produced in 1940 at the University of California, Berkeley, by Edwin McMillan and Phillip Abelson by exposing uranium oxide to neutrons from a cyclotron. The last one, copernicium (#112) was officially recognized in 2009.
This is the latest post in our regular OUPblog column SciWhys. Every month OUP editor and author Jonathan Crowe will be answering your science questions. Got a burning question about science that you’d like answered? Just email it to us, and Jonathan will answer what he can. Today: how do organisms evolve?
The world around us has been in a state of constant change for millions of years: mountains have been thrust skywards as the plates that make up the Earth’s surface crash against each other; huge glaciers have sculpted valleys into the landscape; arid deserts have replaced fertile grasslands as rain patterns have changed. But the living organisms that populate this world are just as dynamic: as environments have changed, so too has the plethora of creatures inhabiting them. But how do creatures change to keep step with the world in which they live? The answer lies in the process of evolution.
Many organisms are uniquely suited to their environment: polar bears have layers of fur and fat to insulate them from the bitter Arctic cold; camels have hooves with broad leathery pads to enable them to walk on desert sand. These so-called adaptations – characteristics that tailor a creature to its environment – do not develop overnight: a giraffe that is moved to a savannah with unusually tall trees won’t suddenly grow a longer neck to be able to reach the far-away leaves. Instead, adaptations develop over many generations. This process of gradual change to make you better suited to your environment is called what’s called evolution.
So how does this change actually happen? In previous posts I’ve explored how the information in our genomes acts as the recipe for the cells, tissues and organs from which we’re constructed. If we are somehow changing to suit our environment, then our genes must be changing too. But there isn’t some mysterious process through which our genes ‘know’ how to change: if an organism finds its environment turning cold, its genome won’t magically change so that it now includes a new recipe for the growth of extra fur to keep it warm. Instead, the raw ‘fuel’ for genetic change is an entirely random process: the process of gene mutation.
In my last post, I considered how gene mutation alters the DNA sequence of a gene, and so alters the information stored by that gene. If you change a recipe when cooking, the end product will be different. And so it is with our genome: if the information stored in our genome – the recipe for our existence – changes, then we must change in some way too.
I mentioned above how the process of mutation is random. A mutation may be introduced when an incorrect DNA ‘letter’ is inserted into a growing chain as a chromosome is being copied: instead of manufacturing a stretch of DNA with the sequence ATTGCCT, an error may occur at the second position, to give AATGCCT. But it’s just as likely that an error could have been introduced at the sixth position instead of the second, with ATTGCCT becoming ATTGCGT. Such mutations are entirely down to chance.
And this is where we encounter something of a paradox. Though the mutations that occur in our genes to fuel the process of evolution do so at random, evolution itself is anything but random. So how can we reconcile this seeming conflict?
To answer this question, let’s imagine a population of sheep, all of whom have a woolly coat of similar thickness. Quite by chance, a gene in one of the sheep in the population picks up a mutation so that offspring of that sheep develop a slightly thicker coat. However, the thick-coated sheep is in a minority: most of the population carry the normal, non-mutated gene, and so have coats of normal thickness. Now, the sheep population live in a fairly temperaAdd a Comment
By Jonathan Crowe Each day of our lives is a battle for survival against an army of invaders so vast in size that it outnumbers the human population hugely. Yet, despite its vastness, this army is an invisible threat, each individual so small that it cannot be seen with the naked eye. These are the microbes – among them the bacteria and viruses – that surround us every day, and could in one way or another kill us were it not for our immune system, an ingenious defence mechanism that protects us from these invisible foes.Add a Comment
Every month OUP editor and author Jonathan Crowe answers your science questions in the monthly SciWhys column. Got a burning question about science that you’d like answered? Just email it to us, and Jonathan will answer what he can. Today: Why do we eat food?
You may well be thinking that the question posed in the title of this blog has an all-too-obvious answer. We all know that we eat food to keep ourselves alive. But why do we find ourselves slaves to our appetites and rumbling stomachs? What is actually happening inside each of us that couldn’t happen without another slice of toast, or piece of fruit, or that most vaunted of mid-afternoon pick-me-ups, the sneakily-consumed bar of chocolate?
We’re all familiar with the concept of something needing fuel to keep it going. Just as a power station requires gas or coal to power its turbines and generate energy, so we need fuel – in the form of food – to power our continued existence.
The foods we eat provide us with a range of nutrients: vitamins, minerals, water, fat, carbohydrates, fibre, and protein. These nutrients are put to different uses — as building materials to construct the tissues and organs from which our bodies are made; as the components of the molecular machinery that keeps our cells running as they should. All of these uses are unified by a common theme: a requirement for energy to make them happen. And this is where one particular type of nutrient comes into its own. Step forward the carbohydrates.
Carbohydrates are better known to us as sugars, but in fact the sweet crystals we know as sugar are only part of this group. Carbohydrates come in very different shapes and sizes. One of the smallest is glucose, which acts as a chemical building block — multiple copies of glucose can join together to form a range of much larger molecules. For example, starch – found in potatoes and flour – is a carbohydrate formed from many individual molecules of glucose joined together in long chains. (Based on taste alone, you wouldn’t think that starch was made of glucose. Even though individual molecules of glucose taste sweet to us, once they are linked together to form starch the sweetness is lost.)
To understand how the sugar in our food can power the processes occurring in our cells every minute of every day, let’s follow some starch on its journey through the body. Many of the foods we consume aren’t in a form with which our bodies can do anything useful. Instead, they need to be digested. And so it is with carbohydrates such as starch. This process of digestion starts as soon as the food enters our mouth; our saliva contains special substances (called enzymes) that start attacking the long chains of starch, breaking it into smaller fragments.
Digestion continues as our food is swallowed and slides down into our stomach, where an arsenal of other chemical weapons set to work on the mouthful we’ve just consumed. Before long, what were initially mouth-watering morsels are reduced to something rather less appetising and leave the stomach to enter the long, snaking tunnel of our intestines. By now, the long chains of starch have been broken down into glucose, which is small enough to pass through the lining of our intestine and into our bloodstream. Our bloodstream acts as a short- and long-distance transport network, carrying the newly-arrived sugar molecules to cells all over the body.
When glucose arrives at its destination and first enters the cell, it uAdd a Comment
In his early twenties, Mendeleev had intuited that the elements followed some kind of order, and he spent thirteen years trying to discover it. In developing his system, he drew on the data and ideas of scientists around the world. Two — Lothar Meyer and British chemist John Alexander Reina Newlands — had published ideas about the periodicity of elements. But Mendeleev’s addressed every known element, which theirs had not.
His system also surpassed the others because he accounted for gaps in the sequence of elements. Mendeleev said that an element would be discovered to fill each gap and even predicted the properties of those elements. The discovery of the one of these missing elements — gallium, in 1875 — helped spur wide acceptance of Mendeleev’s system.
Later work showed that Mendeleev’s reliance on atomic weight to determine periodicity is not completely correct. While atomic weight tends to increase as one moves from element to element, there are exceptions. Mendeleev also did not have the theoretical understanding to explain why the elements exhibited these periodic characteristics. Nevertheless, his achievement marked an important milestone in the understanding of the physical world.
Mendeleev did not personally present his breakthrough to the Chemical Society. Ill on the day of the meeting, he asked a colleague to deliver the report.
Interestingly, the date celebrated for this event reflects Russia’s use of the “Old Style” Julian calendar. According to the “New Style” Gregorian calendar — not adopted in Russia until after 1918 — Mendeleev’s periodic table was presented twelve days later, on March 18.
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From thoughtful commentary on the history of science to an entertaining blend of science and humor, these blogs have very distinct approaches to science but have one thing in common: a driving curiosity about the world around us.Display Comments Add a Comment
Be honest: did you once believe that spaghetti could grow on trees? That cats needed headphones? Or that the moon was made of cheese? Actually, don’t worry about that last one; I’m still sure that’s true. However embarrassingly you may have been hoodwinked on April Fool’s Day in the past, it is incredibly unlikely that you’ll have ever been swindled by French confidence trickster Georges Pierre des Clozets, who represented a completely fictional secret Alchemy society called ‘The Asterism’. That dubious honour fell to Robert Boyle, philosopher, chemist, physicist, and inventor, who was duped in the latter part of the 17th century.
Between 1677 and 1678 Robert Boyle became the victim of a progressive French confidence trickster from Caen called Pierre, who claimed to be the agent of a secret international society of alchemists known mysteriously as ‘The Asterism’. The leader of The Asterism was described as the ‘Patriarch of Antioch’, resident in Constantinople. Pierre claimed to be able to work as an intermediary between Robert Boyle and the head of this exclusive society, Georges du Mesnillet, who Pierre referred to as the Patriarch of Antioch. The Asterism was, allegedly, a society comprised of the leading alchemists from around the world, a society that held the secrets to the riddles that had notoriously plagued Robert Boyle throughout his career. Pierre promised that Boyle would be made a member of The Asterism and, therefore, be privy to these alchemical secrets if he followed his orders.
There were a few problems with this. Firstly, The Asterism was an entirely fictional society made up by Pierre. Secondly, Georges du Mesnillet was not the Patriarch of Antioch (nor was there ever a French Patriarch of Antioch). Georges du Mesnillet was just an old acquaintance of Pierre’s. And thirdly, many of the alchemical secrets Pierre promised to impart were chemically impossible. Of course, Robert Boyle wasn’t to know any of this. Pierre expertly played on Robert Boyle’s obsessive fascination with alchemy, and toyed with Boyle’s perception of what was plausible and, more importantly, what was implausible. At one point during their correspondence, Pierre even managed to convince Boyle that one of the Chinese members of the society based in France had grown a fully formed homunculus in a jar.
So how did Pierre manage to successfully dupe the otherwise incredibly intelligent Robert Boyle?
As well as making a good personal impression on Boyle when the two met in early 1677 – Pierre is alluded to as the ‘illustrious stranger’ and ‘foreign virtuoso’ in Boyle’s An Historical Account of a Degradation of Gold by an Anti-Elixir – the French conman manipulated leading European periodicals to corroborate his fanciful tale. For instance, the stories Pierre told Boyle, such as the Patriarch of Antioch working towards the “reunification of the Greek and Latin Churches”, were backed up in France’s Mercure Galant and Holland’s Haerlemse Courant. The latter was published by Haarlem printer Abraham Casteleyn and it had an excellent reputation for reliability, and for acquiring sensitive international information ahead of its rivals. We also know that Robert Boyle read this publication during the years that Pierre fed ‘information’ to the publishers, and that Boyle was an irenic Christian, so these stories would have appealed to him and helped him believe the lies Pierre was telling him. The artifice of Pierre was such that he made Boyle trust him implicitly.
In early 1678 Robert Boyle was promised by Pierre that a triple-locked chest containing the alchemical secrets of The Asterism would be delivered to him as his membership had been approved by the (pseudo) Patriarch of Antioch. It was at this point that Pierre’s letters to Boyle started to dry up. Pierre’s silence was only punctuated by his bizarre excuse that the delays were due to a freak canon accident that had resulted in him breaking his lower jaw bone and losing part of his forehead. Needless to say, this triggered Boyle’s long overdue scepticism, and soon he found out the embarrassing nature of his correspondence with Pierre and the fictional society of The Asterism.
This embarrassing episode did not just impact on Robert Boyle’s pride, but his bank balance too. Pierre, and the fictional Patriarch of Antioch, swindled Robert Boyle to the tune of several hundred pounds worth of gifts. Amongst many other things, here are a few items Robert Boyle sent Pierre, on the ‘request’ of the Patriarch of Antioch: a telescope, assay balances, a globe, one hundred glass vials, jackets of fine fabric, eight rods of gold-coloured moiré, and a chiming clock over three feet tall. The only gift that we can be sure Boyle received in return, based on the correspondence between them, was a basket of fruits and cheeses. I think it’s fairly obvious who came out on top of that exchange.
Pierre used the gifts and money he had received from Robert Boyle, and numerous other victims throughout the 1670’s, to purchase an extravagant estate in Bretteville in the spring of 1680. While building and planting on the site, Pierre became ill with inflammation of the lung and died in May 1680. His family inherited the estate and the missive that announced his death summed up his mysterious existence perfectly: “Such was the end of this man, whose character had been so little known, and after his death we know even less than when he was alive”.
This article was written by Daniel Parker, Publicity Assistant at OUP, with the help and guidance of the Electronic Enlightenment team. Electronic Enlightenment currently has 13 letters from Georges Pierre Des Clozets to Robert Boyle written in French, along with their English translations. Electronic Enlightenment is a scholarly research project of the Bodleian Libraries, University of Oxford, and is available exclusively from Oxford University Press. It is the most wide-ranging online collection of edited correspondence of the early modern period, linking people across Europe, the Americas, and Asia from the early 17th to the mid-19th century.
The post Georges Pierre des Clozets: the 17th century conman appeared first on OUPblog.
Have you often lain awake at night, wishing that you knew more about cheese? Fear not! Your prayers have been answered; below you will find 18 of the most delicious cheese facts, all taken from Michael Tunick’s recent book The Science of Cheese. Prepare to be the envy of everyone at your next dinner party – just try not to be too “cheesy”. Bon Appétit!
All of these cheese facts are taken from The Science of Cheese. The Science of Cheese is an engaging tour of the science and history of cheese, and the only book to discuss the actual chemistry, biology, and physics of cheese making. Author Michael Tunick is a research chemist with the Dairy and Functional Foods Research Unit of the U.S. Department of Agriculture’s Agricultural Research Service.
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Image credit: Weichkaese Soft Cheese. Photo by Eva K. CC BY-NC-ND 3.0 via Wikimedia Commons.
It was down to the trustworthy sat nav that I arrived safe and sound at Hay Festival this year; torrential downpours meant that navigating was tougher than usual and being told where to go, and when, was more than helpful.
Despite the wet and muddy conditions that met me at Hay, and stayed with me throughout the week, the enthusiasm of the crowd never dwindled. Nothing, it seems, keeps a book lover away from their passion to hear, meet, and have their book signed by their favourite author. But let’s not ignore the fact that festival-goers at Hay not only support their favourite authors, they also relish hearing and discovering new ones.
My working holiday centres on our very own creators of text, our very own exponents of knowledge, our very own Oxford authors! Here I will endeavour to distil just some of the events I was privileged to attend in the call of duty!
Peter Atkins was an Oxford Professor of Chemistry and fellow of Lincoln College, Oxford until his retirement in 2007 – many of us, including myself, studied his excellent text-books at ‘A’ level and at university. What Peter Atkins does so well is make science accessible for everyone and none less so than an attentive Hay audience. Peter puts chemistry right at the heart of science. ‘Chemistry has rendered a service to civilization’ Atkins says ‘it contributes to the cultural infrastructure of the world’. And thereon he took us through just nine things we needed to know to ‘get’ chemistry.
Ian Goldin’s event on Is The Planet Full? addressed global issues that are affecting, and will affect, our planet. So, is the planet full? Well, the Telegraph tent for his talk certainly was! Goldin, whose lime green sweater brought a welcome brightness to the stage, is Professor of Globalisation and Development and Director of the Oxford Martin School at the University of Oxford. His words brought clarity and insight: “politics shapes the answer to this question,” said Goldin.
Hay mixes the young with the old and academics with us mere mortals, and what we publishers call the ‘trade’ authors with the more ‘academic’ types. This was demonstrated aptly by Paul Cartledge who right from the start referenced an earlier talk he attended by James Holland. Cartledge is A.G. Leventis Professor of Greek Culture at University of Cambridge and James (who is an ex-colleague and friend) is a member of the British Commission for Military History and the Guild of Battlefield Guides but a non-academic. The joy of Hay is that it brings everyone together. Paul Cartledge was speaking about After Thermopylae, a mere 2,500 years ago, but rather a more tricky period to illustrate through props and pictures which Holland so aptly used in his presentation.
OUP had 15 authors at The Hay Festival but the Hay Festival also had other visitors such as Chris Evans whose show was broadcast live from the festival as it was the 500 Words competition announcement and I was lucky enough to be there.
So what does Hay mean to me? It’s a unique opportunity to get up close and personal with heroes in literature and culture, as well as academia. It’s a week of friends, colleagues, and drinking champagne with Stephen Fry whilst discussing tennis with John Bercow – and wearing wellies every day!
Kate Farquhar-Thomson is Head of Publicity at OUP in Oxford.
I was reading an advertisement for athletic clothing that featured dry-wick fabric. I have heard my son Don, the runner, extol the virtues of dry-wicking tee shirts and shorts. The idea is that these fabrics will keep you cool, dry, and comfortable no matter how hard you exercise. What’s the science behind how they work and what are they made of, I wondered. The answer arrived a few days later in an article from the Washington Post.
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By Jonathan Crowe
The genetic information stored in our genome – the set of chromosomes that we inherit from our parents – directs the way in which we develop and behave. (We call the attributes and behaviours exhibited by an organism its ‘phenotype’.) Traditionally, the genetic information was thought to be encoded solely in the sequence of the four different chemical building blocks from which our DNA is constructed (that is, our genome sequence). If a DNA sequence changes, so the resulting phenotype changes too. (This is why identical twins, with genomes whose DNA sequences are identical, look the same, but other individuals, whose genomes comprise different DNA sequences, do not.) However, the field of epigenetics opens up a strong challenge to this traditional view of our DNA sequence being the sole dictator of phenotype.
So what actually is epigenetics? In broad terms, epigenetics refers to the way that the information carried in our genome – and the phenotype that results when this information is ‘deciphered’– can be modified not by changes in DNA sequence, but by chemical modifications either to the DNA itself, or to the special group of proteins called histones that associate with DNA in the cell. (It’s a bit like taking a book, with a story told in the author’s words, and adding notes on the page that alter how the story is interpreted by the next person to read it.)
But what has epigenetics to do with the group of four atoms, the one carbon and three hydrogen atoms mentioned at the start of this blog post? These four atoms can combine to form a methyl group – a central carbon atom, with three hydrogen atoms attached; the addition of methyl groups to both DNA and histone proteins in a process called methylation is a primary way in which epigenetic modification occurs. For example, the addition of a methyl group to one of the four chemical building blocks of DNA (called cytosine, C) either when it appears in the sequence CG (where G is the building block called guanine) or the sequence CNG (where N represents any of the four chemical building blocks of DNA) appears to result in that stretch of DNA being ‘switched off’. Consequently, the information stored in that stretch of DNA is not actively used by the cell; that stretch of DNA falls silent.
But what of our queen honeybee? Where does she fit into our story? A queen honeybee has an identical DNA sequence to her workers. Yet she bears some striking differences to them in terms of physical appearance and behavior (amongst other attributes). These differences are more than just skin-deep, however: the pattern of methylation between queen and worker larvae differs. Their genomes may be the same at the level of DNA sequence, but their different patterns of methylation direct different fates: the queen honeybee and her workers develop into quite distinct organisms.
Things take an interesting turn when we consider the cause of these different methylation patterns: the diets that the queen and workers experience during their development. The queen is fed on large quantities of royal jelly into adulthood, while worker larvae face a more meager feast, being switched to a diet of pollen and nectar early on. It is these diets that influence the way in which the queen and worker bees’ genes are switched on and off.
It is not just the queen honeybee whose genome is affected by the environment (in her case, diet). Mice exposed to certain chemicals during pregnancy have beAdd a Comment
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By Jonathan Crowe
As I trudged home that evening, wheeling the now-useless bike beside me, I reflected on the many situations we encounter that mirror this experience – when we find ourselves having to invest energy, only to be no further forward, in real terms, having done so.
Why is it that we have to invest energy merely to maintain the status quo? Why do we find ourselves running, effectively only to stand still? The answer lies in an intrinsic property of all matter, a universal truth so fundamental to our existence that it is captured by its own law: the Second Law of Thermodynamics. This law tells us, in a nutshell, that we are living in a perpetual downward spiral, in which things just get worse. A cheery outlook on life, if ever there was one. But it is an outlook from which there is no escape: the universe, and everything in it, is gradually crumbling into a state of ever-increasing disorder.
This property of all matter – this collapse into disorder – is given a name: entropy. Things that are disordered have greater entropy than things that are relatively more organized. A glass of water, in which the molecules of water itself can move around relatively freely, is more disorganized – has greater entropy – than a block of ice, in which the molecules of water are trapped into a rigid, organized array.
A process that increases disorder, with its associated increase in entropy, is a spontaneous one: one that happens without having to do work to bring it about. This fact has one important corollary: a decrease in entropy – a move towards a more organized state – requires us doing work to bring it about. This is arguably why housework feels like a chore: a living room doesn’t spontaneously tidy itself. We need to invest effort to reverse the spread of disorder, and bring order to whatever degree of chaos had befallen our living space since we last made the effort to tidy up. We are essentially swimming against the natural tide of entropy, with disorder setting in the moment we take our foot off the pedal.
When we look at life at the scale of the molecules and cells of our bodies we continue to see an ongoing battle with entropy: a tussle between order and disorder. Consider proteins, the molecular machines that carry out many important functions in the cell. As they are first being manufactured (or ‘synthesised’) in the cell, proteins exist as elongated chains of conjoined amino acid subunits, much like links of sausages as they are extruded from a sausage-making machine. However, these elongated protein chains must fold into specific three-dimensional shapes to function correctly. This folding represents an increase in order, and hence a decrease in entropy. As we note above, though, swimming against the tide of entropy comes at a cost: the cell must do work to drive such a process forward.
This battle against entropy is essentially why we must eat on a regular basis: to give the cells of our body the energy they need to drive forward those processes that won’t happen spontaneously.
Even the very continuation of life is a battle against disorder. Successful reproduction relies on the passing of biological information from one generation to the next. Every time a cell divides, it must pass on a copy of itsAdd a Comment
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By Jonathan Crowe
But how does DNA, simply a collection of just a few different types of atom, actually store information? To answer this question, we need to consider the structure of DNA in a little more detail. DNA is like a long, thin chain – a chain that is constructed from a series of building blocks joined end-to-end. (In fact, a molecule of DNA features two chains, which line up side-by-side. But we only need to focus on one of these chains to be able to understand how DNA stores its information.)
There are only four different building blocks; these are represented by the letters A, C, G and T. (Each building block has three component parts; one of these parts is made up of one of four molecules: adenine, cytosine, guanine or thymine. It is these names that give rise to letters used to represent the four complete building blocks themselves.) A single DNA molecule is composed of a mixture of these four building blocks, joined together one by one to form a long chain – and it is the order in which the four building blocks are joined together along the DNA chain that lies at the heart of DNA’s information-storing capability.
The order in which the four building blocks appear along a DNA molecule determines what we call its ‘sequence’; this sequence is represented using the single-letter shorthand mentioned above. If we imagine that we had a very small DNA molecule that is composed of just eight building blocks, and these blocks were joined together in the order cytosine-adenine-cytosine-guanine-guanine-thymine-adenine-cytosine, the sequence of this DNA molecule would be CACGGTAC.
The biological information stored in a DNA molecule depends upon the order of its building blocks – that is, its sequence. If a DNA sequence changes, so too does the information it contains. On reflection, this concept – that the order in which a selection of items appears in a linear sequence affects the information stored in that sequence – may not be as alien to us as it might first seem. Indeed, it is the concept on which written communication is based: each sentence in this blog post is composed of a selection of items – the letters of the alphabet – appearing in different sequences. These different sequences of letters spell out different words, which convey different information to the reader.
And so it is with the sequence of DNA: as the sequence of the four building blocks of DNA varies, so too does the information being conveyed. (You may well be asking how the information stored in DNA is actually interpreted – how it actually determines how an organism develops and functions – but that’s a topic for a different blog post.)
You may be wondering how on earth juAdd a Comment
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